Step-by-Step Home DNA Collection: Buccal Swab Instructions & Prep

How to Collect Your DNA Sample at Home: Step-by-Step Buccal Swab Instructions

Our at-home DNA testing kit makes sample collection easy and accurate. Follow these important steps for the best results:

  • Wait at least 30 minutes after eating, drinking, or smoking before collecting your sample.

  • Complete all paperwork before you begin the process.

  • Have your sample envelope ready and within reach.

  • Carefully review your kit instructions to avoid common mistakes.

    For most tests, use the included cheek (buccal) swab for DNA collection.

    Note: For non-invasive prenatal paternity (NIPP) testing, a blood sample from a licensed provider is required. Cheek swabs are not sufficient for NIPP, except for the alleged father only.

    For detailed, visual guides, refer to your kit materials, the guide below or contact our support team if you have questions. Proper preparation ensures fast, accurate results and a smooth testing experience.

Illustration of a crossed-out eating and drinking sign, symbolizing the requirement to avoid food, drink, or smoking 30 minutes before DNA sample collection

Step 1: Prepare for DNA Collection

Wait 30 minutes after eating, drinking, or smoking to ensure a clean DNA sample. Avoid brushing teeth or using mouthwash immediately before swabbing.

Illustration of a hand holding a swab, demonstrating how to collect a DNA sample by rubbing the inside of the cheek

Step 2: Remove the Swab Carefully

Open the swab packaging without touching the fabric tip to any surface. Only handle the swab by the stick for best sample quality.

Illustration showing a person swabbing the inside of their cheek to collect DNA cells for accurate testing

Step 3: Swab Cheeks Thoroughly (30 Seconds Each Side)

Firmly roll the swab against the inside of your cheek for 30 seconds on each side. Target the cheek, not the gums, to collect the most DNA-rich cells.

Illustration of a hand holding a swab in the air for 60 seconds, symbolizing the drying process before storing the DNA sample

Step 4: Air Dry the Swab (60 Seconds)

Wave the swab in the air for one minute if it appears wet. The swab does not need to be completely dry before packaging.

Illustration of a swab being placed into a paper envelope, demonstrating proper storage for DNA sample submission

Step 5: Package Swab Securely

Place the swab into the provided paper sample envelope, avoiding any contact with plastic to prevent sample degradation during shipping.

Parent holding two children outdoors, symbolizing the importance of accurate and reliable home DNA testing for family relationships

Tips for Accurate DNA Test Results

Frequently Asked Questions about Home DNA Test Collection & Buccal Swab Kits

 

  • Swab each cheek firmly for at least 30 seconds as instructed. Use all provided swabs, alternating cheeks, and avoid contact with teeth or gums for the best DNA cell collection.

  • Use a new swab if available. Touching the fabric tip to fingers, counters, or other surfaces may contaminate your sample and affect test results.

  • Only use the swabs supplied in your kit. Regular cotton swabs aren’t designed for DNA preservation and may not be accepted by the lab.

  • Reschedule the collection and wait 30 minutes after last eating, drinking, or smoking to avoid contamination.

  • Use another kit swab if available. If you need a replacement, contact GameDay DNA for a new sample collection kit.

  • Request a new envelope or dry thoroughly before mailing. Wet paper can degrade DNA or cause delays in processing.

  • Using mouthwash or taking medication before swabbing may interfere with DNA cell recovery. Follow guidelines—wait 30 minutes after mouthwash or medication before collection.

  • No—always place swabs into the provided paper sample envelope. Plastic can create moisture and degrade the DNA sample.

  • Paper-packed cheek swabs are viable for testing for several weeks if kept dry and at room temperature. Mail your samples promptly after collection.

  • Follow kit instructions strictly and label each sample. For multi-person tests (paternity, siblings, grandparents), use a separate swab and envelope for each individual.

  • Yes! Call our support team at (302) 527-1789 or order online for help, new kits, or more test options including sibling and grandparent testing.

Need More Help or Ready to Order Your DNA Test?

Still have questions about DNA sample collection, or want to get started today? Our specialists provide fast, confidential support to guide you through every step—so you get accurate results, peace of mind, and answers you can trust.

Order your DNA test kit now or contact us for expert help. Experience secure, reliable DNA testing with GameDay DNA.

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